Conservation of the Segmented Germband Stage: Robustness or Pleiotropy?

Galis F, Van Dooren TJM, & Metz JAJ (2002). Conservation of the Segmented Germband Stage: Robustness or Pleiotropy? IIASA Interim Report. IIASA, Laxenburg, Austria: IR-02-050

[img]
Preview
Text
IR-02-050.pdf

Download (1MB) | Preview

Abstract

Gene expression patterns of the segment polarity genes in the extended and segmented germband stage are remarkably conserved among insects. To explain the conservation of these stages, two hypotheses have been proposed. One hypothesis states that the conservation reflects a high interactivity between modules, so that mutations would have several pleiotropic effects in other parts of the body, resulting in stabilizing selection against mutational variation. The other hypothesis states that the conservation is caused by robustness of the segment polarity network against mutational changes. When evaluating the empirical evidence for these hypotheses, we found strong support for pleiotropy and little evidence supporting robustness of the segment polarity network. This points to a key role for stabilizing selection in the conservation of these stages. Finally, we discuss the implications for robustness of organizers and long-term conservation in general.

Item Type: Monograph (IIASA Interim Report)
Uncontrolled Keywords: Robustness; Modularity; Pleiotropy; Stabilizing-selection; Phylotypic stage; Extended and segmented germband; Organizers
Research Programs: Adaptive Dynamics Network (ADN)
Depositing User: IIASA Import
Date Deposited: 15 Jan 2016 02:14
Last Modified: 08 Nov 2016 19:02
URI: http://pure.iiasa.ac.at/6735

Actions (login required)

View Item View Item

International Institute for Applied Systems Analysis (IIASA)
Schlossplatz 1, A-2361 Laxenburg, Austria
Phone: (+43 2236) 807 0 Fax:(+43 2236) 71 313