Extreme selection in humans against homeotic transformations of cervical vertebrae

Galis F, Van Dooren TJM, Feuth JD, Metz JAJ, Witkam A, Ruinard S, Steigenga MJ, & Wijnaendts LCD (2006). Extreme selection in humans against homeotic transformations of cervical vertebrae. Evolution 60 (12): 2643-2654. DOI:10.1111/j.0014-3820.2006.tb01896.x.

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Abstract

Why do all mammals, except for sloths and manatees, have exactly seven cervical vertebrae? In other vertebrates and other regions, the vertebral number varies considerably. We investigated whether natural selection constrains the number of cervical vertebrae in humans To this end, we determined the incidence of cervical ribs and other homeotic vertebral changes in radiographs of deceased human fetuses and infants, and analyzed several existing datasets on the incidence in infants and adults. Our data show that homeotic transformations that change the number of cervical vertebrae are extremely common in humans, but are strongly selected against: almost all individuals die before reproduction. Selection is most probably indirect, caused by a strong coupling of such changes with major congenital abnormalities. Changes in the number of thoracic vertebrae appear to be subject to weaker selection, in good correspondence with the weaker evolutionary constraint on these numbers. Our analysis highlights the role of prenatal selection in the conservation of our common body plan.

Item Type: Article
Uncontrolled Keywords: Developmental constraint, evolutionary medicine, Hox genes, left-right asymmetry, modularity, phylotypic stage, pleiotropy
Research Programs: Evolution and Ecology (EEP)
Bibliographic Reference: Evolution; 60(12):2643-2654 (December 2006)
Depositing User: IIASA Import
Date Deposited: 15 Jan 2016 02:19
Last Modified: 23 Feb 2016 11:32
URI: http://pure.iiasa.ac.at/7868

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