https://pure.iiasa.ac.at/id/eprint/13887 2021-08-27T17:41:37Z info:eu-repo/semantics/descriptiveMetadata https://pure.iiasa.ac.at/id/eprint/13887/ Use of statins offsets insulin-related cancer risk Kautzky-Willer, A. Thurner, S. Klimek, P. Aim There is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations between individual T2DM therapies, statin use and site-specific cancers in the Austrian population. Methods Medical claims data of 1 847 051 patients with hospital stays during 2006–2007 were used to estimate age- and sex-dependent co-occurrences of site-specific cancer diagnoses and treatment with specific glucose-lowering drugs and statins. Results Patients treated with insulin or insulin secretagogues showed up to ninefold increased risks for cancers of the colon [males only (m)], liver (m), pancreas, lung (m) and brain (m), as well as a strongly decreased risk for prostate cancer (m). In patients taking statins, the risks were generally decreased, with a greater risk reduction in patients not receiving antihyperglycaemic therapies. The strongest effects were observed for use of insulin and pancreatic cancer [m: OR 4.5, 95% CI: 3.1–6.6; females (f): OR 4.2, 95% CI: 2.5–7.1], sulfonylureas (m: OR 2.8, 95% CI: 1.7–4.6; f: OR 3.0, 95% CI: 2.1–4.2) or glitazones and skin cancer (f: OR 0.54, 95% CI: 0.36–0.80), as well as metformin and cancer of the prostate (m: OR 0.82, 95% CI: 0.75–0.91) and corpus uteri (f: OR 1.7, 95% CI: 1.4–2.0) and non-Hodgkin's lymphoma (f: OR 0.76, 95% CI: 0.64–0.91). Conclusions The use of statins offsets insulin-related cancer risks in patients with diabetes independently of sex and age. Overall, our data support the hyperglycaemia–cancer hypothesis. A reduction in endogenous or exogenous hyperinsulinaemia may be beneficial for cancer prevention. Therefore, insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices. Wiley 2017-10-21 Article PeerReviewed Kautzky-Willer, A., Thurner, S. <https://pure.iiasa.ac.at/view/iiasa/307.html>, & Klimek, P. (2017). Use of statins offsets insulin-related cancer risk. Journal of Internal Medicine 281 (2) 206-216. 10.1111/joim.12567 <https://doi.org/10.1111/joim.12567>. 10.1111/joim.12567 10.1111/joim.12567 10.1111/joim.12567 info:eu-repo/semantics/humanStartPage