@prefix epid: <https://pure.iiasa.ac.at/id/> .
  @prefix void: <http://rdfs.org/ns/void#> .
  @prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
  @prefix cc: <http://creativecommons.org/ns#> .
  @prefix ep: <http://eprints.org/ontology/> .
  @prefix eprel: <http://eprints.org/relation/> .
  @prefix doi: <https://doi.org/> .
  @prefix dc: <http://purl.org/dc/elements/1.1/> .
  @prefix bibo: <http://purl.org/ontology/bibo/> .
  @prefix geo: <http://www.w3.org/2003/01/geo/wgs84_pos#> .
  @prefix owl: <http://www.w3.org/2002/07/owl#> .
  @prefix event: <http://purl.org/NET/c4dm/event.owl#> .
  @prefix skos: <http://www.w3.org/2004/02/skos/core#> .
  @prefix foaf: <http://xmlns.com/foaf/0.1/> .
  @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
  @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
  @prefix dct: <http://purl.org/dc/terms/> .

<>
	foaf:primaryTopic <https://pure.iiasa.ac.at/id/eprint/13887>;
	rdfs:comment "The repository administrator has not yet configured an RDF license."^^xsd:string .

<https://pure.iiasa.ac.at/id/eprint/13887#authors>
	rdf:_1 <https://pure.iiasa.ac.at/id/person/ext-f8e897728acc1664bdd2633cec84a8fc>;
	rdf:_2 <https://pure.iiasa.ac.at/id/person/ext-1918>;
	rdf:_3 <https://pure.iiasa.ac.at/id/person/ext-66b8d82a02b6bd355e88f4ae024b6473> .

<https://pure.iiasa.ac.at/id/eprint/13887/>
	dc:format "text/html";
	dc:title "HTML Summary of #13887 \n\nUse of statins offsets insulin-related cancer risk\n\n";
	foaf:primaryTopic <https://pure.iiasa.ac.at/id/eprint/13887> .

<https://pure.iiasa.ac.at/id/eprint/13887>
	bibo:abstract "Aim\r\n\r\nThere is firm evidence of a relation between type 2 diabetes (T2DM) and increased risks of cancer at various sites, but it is still unclear how different antihyperglycaemic therapies modify site-specific cancer risks. The aim of this study was to provide a complete characterization of all possible associations between individual T2DM therapies, statin use and site-specific cancers in the Austrian population.\r\n\r\n\r\nMethods\r\n\r\nMedical claims data of 1 847 051 patients with hospital stays during 2006–2007 were used to estimate age- and sex-dependent co-occurrences of site-specific cancer diagnoses and treatment with specific glucose-lowering drugs and statins.\r\n\r\n\r\nResults\r\n\r\nPatients treated with insulin or insulin secretagogues showed up to ninefold increased risks for cancers of the colon [males only (m)], liver (m), pancreas, lung (m) and brain (m), as well as a strongly decreased risk for prostate cancer (m). In patients taking statins, the risks were generally decreased, with a greater risk reduction in patients not receiving antihyperglycaemic therapies. The strongest effects were observed for use of insulin and pancreatic cancer [m: OR 4.5, 95% CI: 3.1–6.6; females (f): OR 4.2, 95% CI: 2.5–7.1], sulfonylureas (m: OR 2.8, 95% CI: 1.7–4.6; f: OR 3.0, 95% CI: 2.1–4.2) or glitazones and skin cancer (f: OR 0.54, 95% CI: 0.36–0.80), as well as metformin and cancer of the prostate (m: OR 0.82, 95% CI: 0.75–0.91) and corpus uteri (f: OR 1.7, 95% CI: 1.4–2.0) and non-Hodgkin's lymphoma (f: OR 0.76, 95% CI: 0.64–0.91).\r\n\r\n\r\nConclusions\r\n\r\nThe use of statins offsets insulin-related cancer risks in patients with diabetes independently of sex and age. Overall, our data support the hyperglycaemia–cancer hypothesis. A reduction in endogenous or exogenous hyperinsulinaemia may be beneficial for cancer prevention. Therefore, insulin-sparing and insulin-sensitizing drugs should be the preferred treatment choices."^^xsd:string;
	bibo:authorList <https://pure.iiasa.ac.at/id/eprint/13887#authors>;
	bibo:issue "2";
	bibo:status <http://purl.org/ontology/bibo/status/peerReviewed>,
		<http://purl.org/ontology/bibo/status/published>;
	bibo:volume "281";
	dct:creator <https://pure.iiasa.ac.at/id/person/ext-66b8d82a02b6bd355e88f4ae024b6473>,
		<https://pure.iiasa.ac.at/id/person/ext-1918>,
		<https://pure.iiasa.ac.at/id/person/ext-f8e897728acc1664bdd2633cec84a8fc>;
	dct:date "2017-10-21";
	dct:isPartOf <https://pure.iiasa.ac.at/id/repository>,
		<https://pure.iiasa.ac.at/id/publication/ext-09546820>;
	dct:publisher <https://pure.iiasa.ac.at/id/org/ext-e7795bc59c66fd1972aa29b4459edb20>;
	dct:title "Use of statins offsets insulin-related cancer risk"^^xsd:string;
	owl:sameAs <https://doi.org/10.1111/joim.12567>;
	rdf:type bibo:AcademicArticle,
		bibo:Article,
		ep:ArticleEPrint,
		ep:EPrint;
	rdfs:seeAlso <https://pure.iiasa.ac.at/id/eprint/13887/> .

<https://pure.iiasa.ac.at/id/org/ext-e7795bc59c66fd1972aa29b4459edb20>
	foaf:name "Wiley"^^xsd:string;
	rdf:type foaf:Organization .

<https://pure.iiasa.ac.at/id/person/ext-66b8d82a02b6bd355e88f4ae024b6473>
	foaf:familyName "Klimek"^^xsd:string;
	foaf:givenName "P."^^xsd:string;
	foaf:name "P. Klimek"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/person/ext-1918>
	foaf:familyName "Thurner"^^xsd:string;
	foaf:givenName "S."^^xsd:string;
	foaf:name "S. Thurner"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/person/ext-f8e897728acc1664bdd2633cec84a8fc>
	foaf:familyName "Kautzky-Willer"^^xsd:string;
	foaf:givenName "A."^^xsd:string;
	foaf:name "A. Kautzky-Willer"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/publication/ext-09546820>
	bibo:issn "09546820";
	foaf:name "Journal of Internal Medicine"^^xsd:string;
	owl:sameAs <urn:issn:09546820>;
	rdf:type bibo:Collection .