@prefix epid: <https://pure.iiasa.ac.at/id/> .
  @prefix void: <http://rdfs.org/ns/void#> .
  @prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
  @prefix cc: <http://creativecommons.org/ns#> .
  @prefix ep: <http://eprints.org/ontology/> .
  @prefix eprel: <http://eprints.org/relation/> .
  @prefix doi: <https://doi.org/> .
  @prefix dc: <http://purl.org/dc/elements/1.1/> .
  @prefix bibo: <http://purl.org/ontology/bibo/> .
  @prefix geo: <http://www.w3.org/2003/01/geo/wgs84_pos#> .
  @prefix owl: <http://www.w3.org/2002/07/owl#> .
  @prefix event: <http://purl.org/NET/c4dm/event.owl#> .
  @prefix skos: <http://www.w3.org/2004/02/skos/core#> .
  @prefix foaf: <http://xmlns.com/foaf/0.1/> .
  @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
  @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
  @prefix dct: <http://purl.org/dc/terms/> .

<>
	foaf:primaryTopic <https://pure.iiasa.ac.at/id/eprint/4236>;
	rdfs:comment "The repository administrator has not yet configured an RDF license."^^xsd:string .

<https://pure.iiasa.ac.at/id/eprint/4236#authors>
	rdf:_1 <https://pure.iiasa.ac.at/id/person/ext-7540>;
	rdf:_2 <https://pure.iiasa.ac.at/id/person/ext-ca54f507d06c334698009ddf9535c2de>;
	rdf:_3 <https://pure.iiasa.ac.at/id/person/ext-1050> .

<https://pure.iiasa.ac.at/id/eprint/4236/>
	dc:format "text/html";
	dc:title "HTML Summary of #4236 \n\nAntigenic oscillations and shifting immunodominance in HIV-1 infections\n\n";
	foaf:primaryTopic <https://pure.iiasa.ac.at/id/eprint/4236> .

<https://pure.iiasa.ac.at/id/eprint/4236>
	bibo:abstract "Atypical protein antigen contains several epitopes that can be recognized by cytotoxic T lymphocytes (CTL), but in a characteristic antiviral immune response in vivo, CTL recognize only a small number of these potential epitopes, sometimes only one, this phenomenon is known as immunodominance. Antigenic variation within CTL epitopes has been demonstrated for the human immunodeficiency virus HIV-1 and other viruses and such 'antigenic escape' may be responsible for viral persistence. Here we develop a new mathematical model that deals with the interaction between CTL and multiple epitopes of a genetically variable pathogen, and show that the nonlinear competition among CTL responses against different epitopes can explain immunodominance. This model suggests that an antigenically homogeneous pathogen population tends to induce a dominant response against a single epitope, whereas a heterogeneous pathogen population can stimulate complicated fluctuating responses against multiple epitopes. Antigenic variation in the immunodominant epitope can shift responses to weaker epitopes and thereby reduce immuno-logical control of the pathogen population. These ideas are consistent with detailed longitudinal studies of CTL responses in HIV-1 infected patients. For vaccine design, the model suggests that the major response should be directed against conserved epitopes even if they are subdominant."^^xsd:string;
	bibo:authorList <https://pure.iiasa.ac.at/id/eprint/4236#authors>;
	bibo:issue "6532";
	bibo:status <http://purl.org/ontology/bibo/status/nonPeerReviewed>,
		<http://purl.org/ontology/bibo/status/published>;
	bibo:volume "375";
	dct:creator <https://pure.iiasa.ac.at/id/person/ext-1050>,
		<https://pure.iiasa.ac.at/id/person/ext-7540>,
		<https://pure.iiasa.ac.at/id/person/ext-ca54f507d06c334698009ddf9535c2de>;
	dct:date "1995-06";
	dct:isPartOf <https://pure.iiasa.ac.at/id/repository>,
		<https://pure.iiasa.ac.at/id/publication/ext-00280836>;
	dct:publisher <https://pure.iiasa.ac.at/id/org/ext-5e5a54cc3e497cc2c4751d0ad0d5c369>;
	dct:title "Antigenic oscillations and shifting immunodominance in HIV-1 infections"^^xsd:string;
	owl:sameAs <https://doi.org/10.1038/375606a0>;
	rdf:type bibo:AcademicArticle,
		bibo:Article,
		ep:ArticleEPrint,
		ep:EPrint;
	rdfs:seeAlso <https://pure.iiasa.ac.at/id/eprint/4236/> .

<https://pure.iiasa.ac.at/id/org/ext-5e5a54cc3e497cc2c4751d0ad0d5c369>
	foaf:name "Nature Publishing Group"^^xsd:string;
	rdf:type foaf:Organization .

<https://pure.iiasa.ac.at/id/person/ext-1050>
	foaf:familyName "Sigmund"^^xsd:string;
	foaf:givenName "K."^^xsd:string;
	foaf:name "K. Sigmund"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/person/ext-7540>
	foaf:familyName "Nowak"^^xsd:string;
	foaf:givenName "M.A."^^xsd:string;
	foaf:name "M.A. Nowak"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/person/ext-ca54f507d06c334698009ddf9535c2de>
	foaf:familyName "May"^^xsd:string;
	foaf:givenName "R.M."^^xsd:string;
	foaf:name "R.M. May"^^xsd:string;
	rdf:type foaf:Person .

<https://pure.iiasa.ac.at/id/publication/ext-00280836>
	bibo:issn "00280836";
	foaf:name "Nature"^^xsd:string;
	owl:sameAs <urn:issn:00280836>;
	rdf:type bibo:Collection .