This chapter elaborates an organizational approach to regional development programs. The set of organizations, the multiorganization that defines the system under consideration, has a structure—be it formal or informal. We identify this structure by studying the nature of the goals of different member organizations in the context of the development. In this manner one can cluster the organizations into a system structured by levels, each embedded within the other. In this case, where the program is one of regional development one can define a national or general system level that defines the boundaries or general objectives of the regional program. At this level are organizations whose focus considers trade-offs between regional development and other potentially competing activities. Once these trade-offs are worked out and goals defined, the goals are then handed to the set of organizations whose responsibilities are specific to the regional program and that form the regional or program system.