15082 12 80611 2 223015 document 80611 journal.pcbi.1005952.pdf application/pdf 7491cf0d764956296ebb125741d0af1e MD5 6265535 2018-01-26 12:23:43 https://pure.iiasa.ac.at/id/eprint/15082/1/journal.pcbi.1005952.pdf 15082 1 1 application/pdf text en public cc_by

journal.pcbi.1005952.pdf

accepted 80612 1 223024 document 80612 indexcodes.txt text/x-asm 54aa0254c2efe8cf392d4567037d970b MD5 13477 2018-01-26 12:32:41 https://pure.iiasa.ac.at/id/eprint/15082/2/indexcodes.txt 15082 2 2 text/x-asm other Generate index codes conversion from text to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isIndexCodesVersionOf https://pure.iiasa.ac.at/id/document/80611 80613 2 223025 document 80613 lightbox.jpg image/png ff55be6dc3bbba54eaaad4e52eb34ed5 MD5 56460 2018-01-26 12:34:06 https://pure.iiasa.ac.at/id/eprint/15082/3/lightbox.jpg 15082 3 3 image/png other Thumbnails conversion from text to thumbnail_lightbox en public

lightbox.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/islightboxThumbnailVersionOf https://pure.iiasa.ac.at/id/document/80611 80614 2 223026 document 80614 preview.jpg image/png a0a2caff784895d9eaa0439c27729de8 MD5 23511 2018-01-26 12:34:08 https://pure.iiasa.ac.at/id/eprint/15082/4/preview.jpg 15082 4 4 image/png other Thumbnails conversion from text to thumbnail_preview en public

preview.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/ispreviewThumbnailVersionOf https://pure.iiasa.ac.at/id/document/80611 80615 2 223027 document 80615 medium.jpg image/png a8c20d2dab368cd83fa73e716f124b2b MD5 7656 2018-01-26 12:34:09 https://pure.iiasa.ac.at/id/eprint/15082/5/medium.jpg 15082 5 5 image/png other Thumbnails conversion from text to thumbnail_medium en public

medium.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/ismediumThumbnailVersionOf https://pure.iiasa.ac.at/id/document/80611 80616 2 223028 document 80616 small.jpg image/png 7da295beb798e5fbe66c22ae6ebb3592 MD5 2071 2018-01-26 12:34:11 https://pure.iiasa.ac.at/id/eprint/15082/6/small.jpg 15082 6 6 image/png other Thumbnails conversion from text to thumbnail_small en public

small.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/80611 http://eprints.org/relation/issmallThumbnailVersionOf https://pure.iiasa.ac.at/id/document/80611 archive 353 disk0/00/01/50/82 2018-01-26 12:25:33 2021-08-27 17:29:51 2018-01-26 12:25:33 article show Saeki K. Sasaki A. 8233 0000-0003-3582-5865 pub prog_eep Viruses have two modes spread in a host body, one is to release infectious particles from infected cells (global infection) and the other is to infect directly from an infected cell to an adjacent cell (local infection). Since the mode of spread affects the evolution of life history traits, such as virulence, it is important to reveal what level of global and local infection is selected. Previous studies of the evolution of global and local infection have paid little attention to its dependency on the measures of spatial configuration. Here we show the evolutionarily stable proportion of global and local infection, and how it depends on the distribution of target cells. Using an epidemic model on a regular lattice, we consider the infection dynamics by pair approximation and check the evolutionarily stable strategy. We also conduct the Monte-Carlo simulation to observe evolutionary dynamics. We show that a higher local infection is selected as target cells become clustered. Surprisingly, the selected strategy depends not only on the degree of clustering but also the abundance of target cells per se. 2018-01-25 published PLoS 10.1371/journal.pcbi.1005952 267 public PLoS Computational Biology 14 1 e1005952 TRUE 1553-7358 FALSE no info:eu-repo/semantics/article