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DevEvolConstraints2018.pdf

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/86335 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/86335 http://eprints.org/relation/isIndexCodesVersionOf https://pure.iiasa.ac.at/id/document/86335 archive 353 disk0/00/01/56/04 2018-11-29 07:03:20 2021-08-27 17:31:06 2018-11-29 07:03:20 article show Galis F. Metz H. 7506 van Alphen J. pub prog_eep evo-devo, body plan evolution, evolutionary constraint, parthenogenesis, phylotypic stages, regeneration capacity We review the evolutionary importance of developmental mechanisms in constraining evolutionary changes in animals—in other words, developmental constraints. We focus on hard constraints that can act on macroevolutionary timescales. In particular, we discuss the causes and evolutionary consequences of the ancient metazoan constraint that differentiated cells cannot divide and constraints against changes of phylotypic stages in vertebrates and other higher taxa. We conclude that in all cases these constraints are caused by complex and highly controlled global interactivity of development, the disturbance of which has grave consequences. Mutations that affect such global interactivity almost unavoidably have many deleterious pleiotropic effects, which will be strongly selected against and will lead to long-term evolutionary stasis. The discussed developmental constraints have pervasive consequences for evolution and critically restrict regeneration capacity and body plan evolution. 2018-11 published Annual Reviews 10.1146/annurev-ecolsys-110617-062339 206 public Annual Review of Ecology, Evolution, and Systematics 49 1 499-522 TRUE 1543-592X Annual Review of Ecology, Evolution, and Systematics FALSE no info:eu-repo/semantics/article