Approaches to analysing and managing the potential for a threat or hazard to propagate disruptions or losses to multiple connected parts of a complex system are reviewed, and ways IIASA and OECD could enhance their analytical capabilities and rigour of policy advice on systemic financial risk are outlined. IIASA has quantitative methods to measure, model, and manage systemic risk of financial systems using network theory and agent-based modelling. OECD looks into how to operationalise the concept of resilience to systemic risk to give policymakers an effective and efficient resilience management framework. IIASA’s methods can inform and enhance OECD’s framework by making available simple and transparent systemic risk indicators that can be monitored in real-time, as well as tools to test alternative policy interventions to reduce systemic risk. Approaches and models developed to deal with financial systemic risk may also be useful in other networked systems, for example, supply chains.