Increase in testosterone levels is related to a lower risk of conversion of prediabetes to manifest diabetes in prediabetic males

17306 7 94617 2 275392 document 94617 Leutner2021_Article_IncreaseInTestosteroneLevelsIs.pdf application/pdf 906d5c06b0f4e04587965e78ba917d85 MD5 398869 2021-07-06 11:54:13 https://pure.iiasa.ac.at/id/eprint/17306/1/Leutner2021_Article_IncreaseInTestosteroneLevelsIs.pdf 17306 1 1 application/pdf text en public cc_by_4

Leutner2021_Article_IncreaseInTestosteroneLevelsIs.pdf

published 94618 2 275398 document 94618 lightbox.jpg image/png 6baf8f43b7475953ac9c1876bc77a71f MD5 52150 2021-07-06 12:04:18 https://pure.iiasa.ac.at/id/eprint/17306/2/lightbox.jpg 17306 2 2 image/png other Thumbnails conversion from text to thumbnail_lightbox en public

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/94617 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/94617 http://eprints.org/relation/isIndexCodesVersionOf https://pure.iiasa.ac.at/id/document/94617 archive 353 disk0/00/01/73/06 2021-07-06 11:55:46 2021-08-27 17:34:59 2021-07-06 11:55:46 article show Leutner M. Matzhold C. Bellach L. Wohlschläger-Krenn E. Winker R. Nistler S. Endler G. Thurner S. 1918 Klimek P. Kautzky-Willer A. Increase in testosterone levels is related to a lower risk of conversion of prediabetes to manifest diabetes in prediabetic males pub prog_esm Fatty liver; Insulin resistance; Prediabetes; Sex-specific differences; Testosterone. Background: Testosterone plays an important role in the regulation of glucose metabolism. While earlier studies have shown that it has a protective effect in males, unfavorable effects of testosterone on glucose metabolism have been reported in females; however, whether there is a sex-specific relationship between testosterone and glucose metabolism in patients with prediabetes has not been investigated in detail hitherto. Methods: This cross-sectional analysis investigated 423 males and 287 females with diagnosed prediabetes. Detailed assessment of their metabolic profiles was performed, including a 2‑h oral glucose tolerance test (OGTT), HbA1c levels, calculation of insulin resistance with homeostatic model assessment for insulin resistance (HOMA-IR), assessment of lipid metabolism, anthropometric parameters and the fatty liver index (FLI). By using Spearman's correlation test, we investigated the sex-specific relationship between testosterone and metabolism in the prediabetic individuals. Results: In the present study, prediabetic females (mean age 58.6 years, confidence interval [CI: 57.6 y; 59.5 y]) were characterized by lower fasting plasma glucose levels (104.2 mg/dl [CI: 103.0 mg/dl; 105.4 mg/dl] vs. 106.9 mg/dl [CI: 106.0 mg/dl; 107.8 mg/dl]) and a lower FLI (49.5 [CI: 45.7; 53.2] vs. 58.8 [CI: 55.8; 61.8]), but presented with a higher risk of developing manifest type 2 diabetes in the next 10 years (FINDRISK score: 17.6 [CI: 17.1; 18.1] vs. 16.1 [CI: 15.7; 16.5]) when compared to prediabetic males (mean age: 58.04 years [CI: 57.0 y; 59.1 y]). Testosterone was negatively related to insulin resistance (HOMA-IR: Spearman's ρ: -0.33, p < 0.01), 2‑h stimulated glucose levels during the OGTT (ρ = -0.18, p < 0.01), HbA1c levels (ρ = -0.13, p < 0.05), FLI and BMI in prediabetic males; however, no relationship between testosterone and metabolic parameters could be found in prediabetic females. Conclusion: The increase of testosterone levels in males was related to a more favorable glucose metabolism, including lower HbA1c, lower stimulated glucose levels and higher insulin sensitivity; however, in prediabetic females, testosterone was not related to glucose metabolism. 2021-07-05 published Springer 10.1007/s00508-021-01903-1 307 public Wiener klinische Wochenschrift TRUE 0043-5325 FALSE no info:eu-repo/semantics/article