17953 14 98018 2 301604 document 98018 1-s2.0-S1201971222001977-main.pdf application/pdf d91b83327e2598899d698736188fe4fc MD5 1083563 2022-06-12 06:07:33 https://pure.iiasa.ac.at/id/eprint/17953/1/1-s2.0-S1201971222001977-main.pdf 17953 1 1 application/pdf text en public cc_by_nc_nd_4

1-s2.0-S1201971222001977-main.pdf

published 98019 2 301606 document 98019 lightbox.jpg image/png 387cb2c8f29b2bfc33a071727194eeb1 MD5 57461 2022-06-12 06:08:04 https://pure.iiasa.ac.at/id/eprint/17953/2/lightbox.jpg 17953 2 2 image/png other Thumbnails conversion from text to thumbnail_lightbox en public

lightbox.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/islightboxThumbnailVersionOf https://pure.iiasa.ac.at/id/document/98018 98020 2 301607 document 98020 preview.jpg image/png 78159eec63bc610e2a8db8a1bfe62acc MD5 24620 2022-06-12 06:08:05 https://pure.iiasa.ac.at/id/eprint/17953/3/preview.jpg 17953 3 3 image/png other Thumbnails conversion from text to thumbnail_preview en public

preview.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/ispreviewThumbnailVersionOf https://pure.iiasa.ac.at/id/document/98018 98021 2 301608 document 98021 medium.jpg image/png 1fbfad595a174456a8fac848c0c9e89c MD5 7963 2022-06-12 06:08:06 https://pure.iiasa.ac.at/id/eprint/17953/4/medium.jpg 17953 4 4 image/png other Thumbnails conversion from text to thumbnail_medium en public

medium.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/ismediumThumbnailVersionOf https://pure.iiasa.ac.at/id/document/98018 98022 2 301609 document 98022 small.jpg image/png f760defc851f21b4e5a267bad1ecd47f MD5 1877 2022-06-12 06:08:07 https://pure.iiasa.ac.at/id/eprint/17953/5/small.jpg 17953 5 5 image/png other Thumbnails conversion from text to thumbnail_small en public

small.jpg

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/issmallThumbnailVersionOf https://pure.iiasa.ac.at/id/document/98018 98023 1 301610 document 98023 indexcodes.txt text/x-asm 083d2d81bce55548eb9f6b62e8dea281 MD5 9519 2022-06-12 06:08:22 https://pure.iiasa.ac.at/id/eprint/17953/6/indexcodes.txt 17953 6 6 text/x-asm other Generate index codes conversion from text to indexcodes en public

indexcodes.txt

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/98018 http://eprints.org/relation/isIndexCodesVersionOf https://pure.iiasa.ac.at/id/document/98018 archive 353 disk0/00/01/79/53 2022-04-11 12:17:03 2025-10-01 13:14:29 2022-04-11 12:17:03 article show di Lego V. Sanchez-Romero M. 9468 0000-0002-5999-6522 Prskawetz A. 2025 pub ASA EM POPJUS SHAW EF H2A Breakthrough Infections; COVID-19; Case-Fatality Rate; Vaccine effectiveness Objectives: Test the behavior of the case fatality rate in a mixed population of vaccinated and unvaccinated individuals by illustrating the role of both the effectiveness of vaccines in preventing deaths and the detection of infections among both the vaccinated (breakthrough infections) and unvaccinated individuals. Methods: We simulate three hypothetical case fatality rate scenarios that result from a different combination of vaccine effectiveness in preventing deaths and the efforts in detecting infections among both the vaccinated and unvaccinated individuals. Results: In the presence of vaccines, the case fatality rate depends not only on the effectiveness of vaccines in preventing deaths, but also on the detection of breakthrough infections. As a result, a decline in the case fatality rate may not imply that vaccines are being effective in reducing deaths. Likewise, a constant case fatality rate can still mean that vaccines are effective in reducing deaths. Conclusions: Unless vaccinated people are also tested, the case fatality rate loses its meaning in tracking the pandemic. This shows that unless efforts are directed at detecting breakthrough infections, it is hard to disentangle the effect of vaccines in reducing deaths from the probability of detecting infections on the case fatality rate. 2022-06-01 published 10.1016/j.ijid.2022.03.059 3415 100 public International Journal of Infectious Diseases 119 178-183 TRUE 12019712 no info:eu-repo/semantics/article