18732 9 105689 2 321336 document 105689 WP-23-005.pdf application/pdf 8ef5516d30a5e5a6d564c1d1bbb0c688 MD5 1610249 2024-04-17 07:44:31 https://pure.iiasa.ac.at/id/eprint/18732/1/WP-23-005.pdf 18732 1 1 application/pdf text en public cc_by_nc_4

WP-23-005.pdf

published 105690 1 321338 document 105690 indexcodes.txt text/x-c++ 2a3b138890abda8ef17bfff761909764 MD5 16129 2024-04-17 07:45:23 https://pure.iiasa.ac.at/id/eprint/18732/2/indexcodes.txt 18732 2 2 text/x-c++ other Generate index codes conversion from text to indexcodes en public

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/105689 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/105689 http://eprints.org/relation/ismediumThumbnailVersionOf https://pure.iiasa.ac.at/id/document/105689 105694 2 321342 document 105694 small.jpg image/png 613dfbfd9710e524d87239f1cd641b24 MD5 1562 2024-04-17 07:55:03 https://pure.iiasa.ac.at/id/eprint/18732/6/small.jpg 18732 6 6 image/png other Thumbnails conversion from text to thumbnail_small en public

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/105689 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/105689 http://eprints.org/relation/issmallThumbnailVersionOf https://pure.iiasa.ac.at/id/document/105689 archive 353 disk0/00/01/87/32 2023-04-21 10:43:45 2025-03-12 05:01:04 2023-04-21 10:43:45 monograph show 2 Rella S.A. Kulikova Y. 2358 0000-0002-5243-4279 Minnegalieva A.R. Kondrashov F.A. Michael Kohn, Economic Frontiers pub EF Fertility, rural, urban, fertility differentials, education, demographic and health surveys Vaccination is the most effective tool to control infectious diseases. However, the evolution of vaccine resistance, exemplified by vaccine-resistance in SARS-CoV-2, remains a concern. Here, we model complex vaccination strategies against a pathogen with multiple epitopes - molecules targeted by the vaccine. We found that a vaccine targeting one epitope was ineffective in preventing vaccine resistance. Vaccine resistance in highly infectious pathogens was prevented by the full-epitope vaccine, one targeting all available epitopes, but only when the rate of pathogen evolution was low. Strikingly, a bet-hedging strategy of random administration of vaccines targeting different epitopes was the most effective in preventing vaccine resistance in pathogens with low rate of infection and high rate of evolution. Thus, complex vaccination strategies, when biologically feasible, may be preferable to the currently used single-vaccine approaches for long-term control of disease outbreaks, especially when applied to livestock with near 100% vaccination rates. 2023-04-20 published WP-23-005 3411 public working_paper Laxenburg, Austria FALSE no info:eu-repo/semantics/book