Minor variations in multicellular life cycles have major effects on adaptation

18738 10 104380 2 318099 document 104380 journal.pcbi.1010698.pdf application/pdf 6f2edcf189264d1a1af0cd83b477c1f3 MD5 2291470 2024-01-05 14:06:30 https://pure.iiasa.ac.at/id/eprint/18738/1/journal.pcbi.1010698.pdf 18738 1 1 application/pdf text en public cc_by_4

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published 104390 1 318130 document 104390 indexcodes.txt text/x-c++ 2d3c0086bc0045357c753a9c9575709e MD5 14736 2024-01-05 14:16:50 https://pure.iiasa.ac.at/id/eprint/18738/2/indexcodes.txt 18738 2 2 text/x-c++ other Generate index codes conversion from text to indexcodes en public

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/104380 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/104380 http://eprints.org/relation/issmallThumbnailVersionOf https://pure.iiasa.ac.at/id/document/104380 archive 353 disk0/00/01/87/38 2023-04-24 09:19:19 2024-01-05 14:06:59 2023-04-24 09:19:19 article show Isaksson H. Brännström Å. 8085 Libby E. Minor variations in multicellular life cycles have major effects on adaptation pub ASA CAT EM Multicellularity has evolved several independent times over the past hundreds of millions of years and given rise to a wide diversity of complex life. Recent studies have found that large differences in the fundamental structure of early multicellular life cycles can affect fitness and influence multicellular adaptation. Yet, there is an underlying assumption that at some scale or categorization multicellular life cycles are similar in terms of their adaptive potential. Here, we consider this possibility by exploring adaptation in a class of simple multicellular life cycles of filamentous organisms that only differ in one respect, how many daughter filaments are produced. We use mathematical models and evolutionary simulations to show that despite the similarities, qualitatively different mutations fix. In particular, we find that mutations with a tradeoff between cell growth and group survival, i.e. "selfish" or "altruistic" traits, spread differently. Specifically, altruistic mutations more readily spread in life cycles that produce few daughters while in life cycles producing many daughters either type of mutation can spread depending on the environment. Our results show that subtle changes in multicellular life cycles can fundamentally alter adaptation. 2023-04-21 published PLoS doi:10.1371/journal.pcbi.1010698 39 public PLoS Computational Biology 19 4 e1010698 TRUE 1553-7358 no info:eu-repo/semantics/article