Multi-hazard and multi-risk contexts are increasingly recognised as central to disaster risk reduction and climate adaptation. While there is a recognised need to move beyond single-hazard and single-sector approaches, practical frameworks for systemic multi-hazard and multi-risk assessment remain scarce. In response, the Horizon 2020 MYRIAD-EU project developed a conceptual framework grounded in systemic risk research and structured around a six-step iterative process. This paper critically reflects on its implementation across five European pilot regions . Using project deliverables, a survey, and a focus group, we assess the framework’s strengths and limitations, and distil lessons learned from both its development and its practical application. These lessons learned are that the framework provides a valuable roadmap for structuring complexity, fostering dialogue with stakeholders, and distinguishing direct from indirect risks. However, challenges remain regarding data, capacity, tool integration, and communication. We conclude with recommendations for improving usability, institutionalisation, and long-term uptake.