Continuity in Evolution: On the Nature of Transitions

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/4508 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/4508 http://eprints.org/relation/isCoversheetVersionOf https://pure.iiasa.ac.at/id/document/4508 archive 351 disk0/00/00/56/09 2016-01-15 02:10:21 2021-08-27 17:16:28 2016-01-15 02:10:21 monograph show 3 Fontana W. 1629 Schuster P. AL1641 Continuity in Evolution: On the Nature of Transitions pub iis_ecl iis_mod prog_adn To distinguish continuous from discontinuous evolutionary change, a relation of nearness between phenotypes is needed. Such a relation is based on the probability of one phenotype being accessible from another through changes in the genotype. This is exemplified by calculating the shape neighborhood of a tRNA secondary structure, and provides a characterization of discontinuous shape transformations in RNA. The simulation of replicating and mutating RNA populations under selection shows that sudden adaptive progress coincides mostly, but not always, with discontinuous shape transformations. The nature of these transformations illuminates the key role of neutral genetic drift in their realization. 1998-04 published IR-98-039 IR-98-039 1257 2671 public interim_report IIASA, Laxenburg, Austria 18 FALSE info:eu-repo/semantics/book