This paper provides the background and the context for the analyses presented  in the seven papers of this Special Issue on Integrated Assessment of Uncertainties in Greenhouse Gas Emissions and their Mitigation. First, the main topic and content of the Special Issue is given, followed by an overall overview. Second, detailed overviews and summaries of the seven  papers are given. The specific analytical and methodological features and findings of each paper are highlighted and the linkages between the various papers presented in the Special Issue are provided.