Evolution of DNA Double-Strand Break Repair by Gene Conversion: Coevolution Between a Phage and Restriction-Modification System

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IR-07-060.pdf

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IR-07-060.pdf

http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/13121 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/13121 http://eprints.org/relation/isCoversheetVersionOf https://pure.iiasa.ac.at/id/document/13121 archive 351 disk0/00/00/83/98 2016-01-15 08:40:21 2021-08-27 17:20:06 2016-01-15 08:40:21 monograph show 2 Yahara K. Horie R. Kobayashi I. Sasaki A. 8233 0000-0003-3582-5865 Evolution of DNA Double-Strand Break Repair by Gene Conversion: Coevolution Between a Phage and Restriction-Modification System pub iis_ecl prog_eep The necessity to repair genome damage has been considered to be an immediate factor responsible for the origin of sex. Indeed, attack by a cellular restriction enzyme of invading DNA from several bacteriophages initiates recombinational repair by gene conversion if there is homologous DNA. In the present work, we modeled the interaction between a bacteriophage and a bacterium carrying a restriction enzyme as antagonistic coevolution. We assume a locus on the bacteriophage genome has either a restriction-sensitive or a -resistant allele, and another locus determines whether it is recombination/repair-proficient or -defective. A restriction break can be repaired by a co-infecting phage genome if one of them is recombination/repair-proficient. We define the fitness of phage (resistant/sensitive and repair-positive/-negative) genotypes and bacterial (restriction-positive/-negative) genotypes by assuming random encounter of the genotypes, with a given probabilities of single and double infections, and the costs of resistance, repair and restriction. Our results show the evolution of the repair allele depends on b1 / b0 , the ratio of the burst size b1 under damage to host cell physiology induced by an unrepaired double-strand break to the default burst size b0 . It was not until this effect was taken into account that the evolutionary advantage of DNA repair became apparent. 2007-12 published IR-07-060 IR-07-060 267 public interim_report IIASA, Laxenburg, Austria 31 FALSE info:eu-repo/semantics/book