Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer

8792 8 61318 3 168766 document 61318 Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer.pdf application/pdf 14e114388b3f5d66462f6616eab3473e MD5 490992 2016-06-09 11:40:52 https://pure.iiasa.ac.at/id/eprint/8792/1/Evolutionary%20maintenance%20of%20selfish%20homing%20endonuclease%20genes%20in%20the%20absence%20of%20horizontal%20transfer.pdf 8792 1 1 application/pdf text en public cc_by_nc

Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer.pdf

published 61319 2 168769 document 61319 lightbox.jpg image/png 772b3e0e654a7f9e0918af0cf90acb61 MD5 81897 2016-06-09 11:41:23 https://pure.iiasa.ac.at/id/eprint/8792/2/lightbox.jpg 8792 2 2 image/png other Thumbnails conversion from text to thumbnail_lightbox en public

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http://eprints.org/relation/isVersionOf https://pure.iiasa.ac.at/id/document/61318 http://eprints.org/relation/isVolatileVersionOf https://pure.iiasa.ac.at/id/document/61318 http://eprints.org/relation/isIndexCodesVersionOf https://pure.iiasa.ac.at/id/document/61318 archive 351 disk0/00/00/87/92 2016-01-15 08:41:52 2021-08-27 17:20:37 2016-01-15 08:41:52 article show 1 Yahara K. Fukuyo M. Sasaki A. 8233 0000-0003-3582-5865 Kobayashi I. Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer pub iis_ecl prog_eep Haploid-diploid cycle; Horizontal gene transfer; Meiosis; Selfish gene; VDE Homing endonuclease genes are "selfish" mobile genetic elements whose endonuclease promotes the spread of its own gene by creating a break at a specific target site and using the host machinery to repair the break by copying and inserting the gene at this site. Horizontal transfer across the boundary of a species or population within which mating takes place has been thought to be necessary for their evolutionary persistence. This is based on the assumption that they will become fixed in a host population, where opportunities of homing will disappear, and become susceptible to degeneration. To test this hypothesis, we modeled behavior of a homing endonuclease gene that moves during meiosis through double-strand break repair. We mathematically explored conditions for persistence of the homing endonuclease gene and elucidated their parameter dependence as phase diagrams. We found that, if the cost of the pseudogene is lower than that of the homing endonuclease gene, the 2 forms can persist in a population through autonomous periodic oscillation. If the cost of the pseudogene is higher, 2 types of dynamics appear that enable evolutionary persistence: bistability dependent on initial frequency or fixation irrespective of initial frequency. The prediction of long persistence in the absence of horizontal transfer was confirmed by stochastic simulations in finite populations. The average time to extinction of the endonuclease gene was found to be thousands of meiotic generations or more based on realistic parameter values. These results provide a solid theoretical basis for an understanding of these and other extremely selfish elements. 2009-11 published National Academy of Sciences 10.1073/pnas.0908404106 XJ-09-134 PNAS; 106(44):18861-18866 (3 November 2009) [doi:10.1073/pnas.0908404106] 267 public Proceedings of the National Academy of Sciences 106 44 18861-18866 TRUE 1091-6490 FALSE info:eu-repo/semantics/article